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Effects of early intervention of Clostridium butyricum on intestinal flora and short chain fatty acids in broilers

This experiment was conducted to study the effects of early intervention of Clostridium butyricum (Clostridium butyricum) on intestinal short-chain fatty acids (SFAs) and flora structure of Enterotoxigenic Escherichia coli (ETEC) in broilers. 200 1-day-old ROSS broilers were selected and divided into two groups, 100 in each group. Three days before the experiment, one group was fed with 1mL of Clostridium butyricum with a concentration of 109 CFU/mL every day, and the other group was fed with 1mL of normal saline. At 7 days of age, broilers fed with saline were divided into control group (Control) and E. coli group (EC). Broilers fed with Clostridium butyricum were divided into Clostridium butyricum group (CB) and Clostridium butyricum E. coli group (CB EC). From the age of 7 days to the end of the experiment, EC group and CB EC group were fed with 1mL(108 CFU/mL) enterotoxigenic E. coli solution for challenge, while Control group and CB group were fed with 1mL normal saline. Slaughter sampling at 3d and 7d after ETEC challenge. The results showed that: ① In the caecum of broilers, at the age of 10 days, compared with the Control group, the acetic acid content in CB group was significantly increased (P<0.01), and the acetic acid content in EC group was significantly decreased (P<0.05). The content of butyric acid in CB group and CB EC group is relatively similar, and is significantly higher than that in Control group and EC group (P<0.01). At 14 days of age, compared with Control group, the contents of acetic acid, propionic acid, butyric acid and isobutyric acid in CB group were significantly increased (P<0.05), while those in EC group were significantly decreased (P<0.05). ②At the age of 10 days, in the CB group, the relative abundance of rumen cocci was the highest, which was significantly higher than that of the other experimental groups (P<0.05). It can be seen that the early intervention of Clostridium butyricum in broilers can promote the production of intestinal short-chain fatty acids and improve the structure of cecal flora to a certain extent. The full text has been published in the 11th issue of Feed Industry in 2021.

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